منابع مشابه
Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications.
Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation. TF expression and activity can be induced in endothelial cells, vascular smooth muscle cells, and monocytes by various stimuli such as cytokines, growth factors, and biogenic amines....
متن کاملTissue Factor and Cardiovascular Disease:
Under physiological conditions, the coagulation system is designed to maintain the circulating blood in a fluid state, but act towards restoration of vascular integrity by rapid clot formation after vessel injury. Historically, the coagulation cascade was divided into 2 major systems: the extrinsic and the intrinsic pathway (Figure 1).1 The tissue factor (TF)factor VII/VIIa (FVII/FVIIa) complex...
متن کاملTissue engineering therapy for cardiovascular diseases.
Cardiovascular Diseases To the Editor: We read with interest the review by Nugent and Edelman.1 The authors have discussed seeding of prosthetic vascular graft but have not commented on the difference between single-stage and two-stage seeding. Single-stage seeding involves extraction of endothelial cells (ECs), coating of graft lumen, and implanting the graft into the patient, all within the t...
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introduction: cardiac dysfunctions have been well known in patients with major thalassemia. some studies have focused on differences in blood pressure and heart rate between these patients and normal population, while this view has not been proven in other studies. given the importance of hemodynamic factors in the health of these individuals, we intend to test the hypothesis as to whether or n...
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UNLABELLED Infantile and juvenile obesity is a medical, social and cultural problem, which reaches epidemic proportions worldwide. In Romania, according to the World Health Organization, one out of four Romanians is obese. As far as infantile obesity is concerned, Romania ranks third in Europe. Infantile obesity has a major impact on all body systems and is associated with risk factors for card...
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ژورنال
عنوان ژورنال: Circulation
سال: 2006
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.567297